Factor Vill - Induced Superaggregation of Human Platelets
نویسندگان
چکیده
High concentrations of bovine factor VIII cause clumping of platelets into a few very large aggregates. This response is termed superaggregation. It is distinct from factor-VIIIinduced agglutination but is also independent of both extracellular calcium ions and platelet energy metabolism. Neither agglutinating lectins nor aggregating agents. including thrombin. ADP. the ionophore A231 87. and U4661 9. a prostaglandin analog. can induce superaggregation. even at very high concentrations. Washed platelets undergo superaggregation. and superaggregation does not increase the amounts of fibrinogen or albumin trapped by agglutinated platelets. It is not inhibited by membranestabilizing drugs or by colchicine or cytochalasin-B. Formaldehyde and glutaraldehyde prevent superaggregation
منابع مشابه
Factor VIII-induced superaggregation of human platelets.
High concentrations of bovine factor VIII cause clumping of platelets into a few very large aggregates. This response is termed superaggregation. It is distinct from factor-VIII-induced agglutination but is also independent of both extracellular calcium ions and platelet energy metabolism. Neither agglutinating lectins nor aggregating agents, including thrombin, ADP, the ionophore A23187, and U...
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